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KMID : 0378019950380120071
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New Medical Journal
1995 Volume.38 No. 12 p.71 ~ p.75
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Naloxone versus Nalbuphine for Treatment of Side Effects following Epidural Morphine
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Abstract
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Epidural morphine provides excellent postoperative analgesia but is associated with high incidence of side effects such as nausea, vomiting and pruritus. To treat all these side effects, specific opioid antagonists such as naloxone and nalbuphine have been used. This study compared naloxone and nalbuphine when administered for treatment of side effects following epidural morphine.
Patients requesting treatment for nausea/vomiting or pruritus randomly received, in a double-blind fashion, up to three intravenous doses of either naloxone 0.2 mg (group 1; n=20) or nalbuphine 5 mg (group 2; n=20). The severity of nausea/vomiting and pruritus, and the degree of sedation and pain were assessed before and 30 min after each dose.
The first dose of naloxone and nalbuphine decreased the nausea/vomiting and pruritus severity scores significantly (p<0.001), but there were no significant differences between naloxone and nalbuphine. Pain scores and sedation scores remained unchanged after both naloxone and nalbuphine.
In conclusion, we found that both naloxone and nalbuphine were excellent for treatment of side effects following epidural morphine but there were no significant differences between two groups.
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